30 male rats weighing about 200 gm were used, and the experiment was done with 20% alcohol group, 40% alcohol group, and the control group. 5 gm per Kg body weight was administrational orally in the experimental group. According to the administration day, the ultrastructure of the liver cell was observed, and then obtained the following results:
1. In the 20% alcohol group, the increment of the lysosomes and the lipid droplets were observed on the 3rd day, the slight change of rough endoplasmic reticulum began to show on the 5 th day, the slight swelling phenomenon of the mitochondria and cisternae of rough endoplasmic reticulum were observed, and smooth endoplasmic reticulum was increased on the 10th day, and then the swelling and destructive phenomenon of the mitochondria and rough endoplasmic reticulum showed, and the smooth endoplasmic reticulum was increased remarkably on the 20th day.
2. In the 40% alcohol group, the increment of the lysosomes and the mitochondria showed, and the lipid droplets were observed remarkably on the 3rd day, the slight swelling of rough endoplasmic reticulum and the increment of smooth endoplasmic reticulum were observed on the 5th day, and then the swelling and destructive phenomenon of mitochondria and cisternae of rough endoplasmic reticulum showed remarkably on the 10th day, the destructive rough endoplasmic reticulum were generally observed on the 20th day.
From the above results, the pathological phenomenon of the liver cell by alcoholism was observed on the 20th day in the low concentration, and on the 10th day in the high concentration.
|